Miguel Alcalde Group


Miguel Alcalde

Prof. Alcalde studied Biology at the Universidad Complutense de Madrid, Spain (1988-1993) and in 1994, he obtained an M.Sc in Plant Physiology. In 1999, he completed his PhD in Biochemistry and Molecular Biology at the Institute of Catalysis (ICP-CSIC, Madrid). From 2001 to 2003, Dr. Alcalde took up a postdoctoral position at CALTECH under the guidance of Prof. Frances H. Arnold.

After his return to ICP-Madrid, he was appointed as Staff Scientist of the CSIC, promoted to CSIC Researcher in 2014 and to full CSIC Professor in 2019. Dr. Alcalde has participated in several consecutive European Projects and research contracts with industries. Dr. Alcalde is co-author of several patents and over 100-SCI papers.


Campus Cantoblanco
28049 Madrid, Spain.

Phone & Fax

Research Interest:

The central aim of Dr Alcalde’s laboratory is to develop more robust enzymes with versatile applications by directed molecular evolution. In particular, our current research focuses on the engineering of ligninolytic oxidoreductases (high redox potential laccases, peroxidases, peroxygenases, hydrogen peroxide suppling enzymes) for medical, environmental and energetic applications. Our research goals include developing new strategies to generate diversity in Saccharomyces cerevisiae, as well as tailoring high-throughput screening methods to assay mutant libraries generated by a combination of directed evolution and rational approaches.

Positions are open for highly motivated postdoctoral researchers, graduate students and undergraduates with backgrounds in biochemistry, molecular biology, chemistry, chemical engineering and genetics.

Miguel Alcalde Laboratory
Institute of Catalysis, ICP-CSIC,
Cantoblanco, 28049, Madrid, Spain
Tel: +34 915854806
Fax: +34 915854760

Miguel de Abreu

Manager Business Development, 3P Biopharmaceuticals, Belfast, UK.

Susana Camarero

CSIC Staff Scientist, CIB-CSIC, Madrid, Spain.

Katarina Elbl-Müllhofer

Engineer at Testo Industrial Services, GmbH, Germany.

Layla Fernandez

Group Leader Protein Engineering in Evoxx technologies, GmbH, Germany.

Carlos Garcia-Burgos

Senior Regulatory Affairs Manager at Acino Pharma AG, Switzerland.

Iraj Ghazi

Scientist at Homology Medicines, Inc, Boston, USA.

David Gonzalez-Perez

Postdoc Scientist at Moffit Cancer Center & Research Institute, Florida, USA.

Mehdi Imani

Associate Professor at Urmia University, Iran.

Adinnaraya Kunamneni

PhD researcher at University of Kentucky, Kentucky State, USA.

Diego Jimenez-Lalana

Predoctoral fellow at CNB-CSIC, Madrid, Spain.

Macarena Lopez

Scientist Process Development CMC, Seville, Spain.

Diana Mate

Talent Attraction Researcher at University Autónoma de Madrid, Spain.

Javier Martin-Diaz

Titulado Superior de actividades técnicas y profesionales CSIC, Spain.

Seyed Mohammad Mosthtaghioun

Academic Staff at Yazd University, Iran.

Miguel Arcangel Palomino-Lopez

Biologist at Andujar town hall, Spain.

Alina Roman

Senior Technologist at Lonza, London, UK.

Pamela Torres-Salas

Senior Technologist at Repsol, Madrid, Spain.

Ana Isabel Vicente-Martin

Account manager at Gilson, Madrid, Spain.

Miren Zumarraga

Senior Scientist at Guserbiot, Vitoria, Spain.