Miguel Alcalde Group
Dr. Alcalde studied Biology at the Universidad Complutense de Madrid, Spain (1988-1993) and in 1994, he obtained an M.Sc in Plant Physiology. In 1999, he completed his PhD in Biochemistry and Molecular Biology at the Institute of Catalysis (ICP-CSIC, Madrid). From 2001 to 2003, Dr. Alcalde took up a postdoctoral position at CALTECH under the guidance of Prof. Frances H. Arnold.
After his return to ICP-Madrid, he was appointed as Staff Scientist of the CSIC and promoted to CSIC Researcher in 2014. Dr. Alcalde has participated in several consecutive European Projects and research contracts with industries. Dr. Alcalde is co-author of several patents and over 90-SCI papers.
The central aim of Dr Alcalde’s laboratory is to develop more robust enzymes with versatile applications by directed molecular evolution. In particular, our current research focuses on the engineering of ligninolytic oxidoreductases (high redox potential laccases, peroxidases, peroxygenases, hydrogen peroxide suppling enzymes) for medical, environmental and energetic applications. Our research goals include developing new strategies to generate diversity in Saccharomyces cerevisiae, as well as tailoring high-throughput screening methods to assay mutant libraries generated by a combination of directed evolution and rational approaches.
Positions are open for highly motivated postdoctoral researchers, graduate students and undergraduates with backgrounds in biochemistry, molecular biology, chemistry, chemical engineering and genetics.