Miguel Alcalde Group

Reshaping enzymes for biotechnology

Miguel Alcalde Group

Reshaping enzymes for biotechnology

Miguel Alcalde Group

Reshaping enzymes for biotechnology

Miguel Alcalde Group

Reshaping enzymes for biotechnology

DIRECTED ENZYME EVOLUTION GROUP AT ICP-CSIC

Welcome to Miguel Alcalde group at the Institute of Catalysis (ICP, CSIC, Madrid). Our research primarily focusses on the engineering of enzymes by directed evolution and computational design for a wide range of biotechnological purposes; the development of high-throughput biomolecular screening tools and genetic methods for library construction and exploration, as well as synthetic biology studies for environmental and energy applications.

DIRECTED EVOLUTION

Designing ad-hoc enzymes for industrial applications

1. Development of high-throughput screening assays

Highly sensitive and reliable screening assays to improve different biochemical traits.

2. Design of DNA recombination methods

Broad portfolio of library creation methods based on the high frequency of homologous recombination of Saccharomyces cerevisiae.

3. Analysis of mutant libraries assisted by computational algorithms.

Directed evolution and computational methods are combined aimed at reducing screening efforts.

Latest Publications

Miguel Alcalde Laboratory

 

Institute of Catalysis, ICP-CSIC
Cantoblanco 28049, Madrid, Spain.
Tel: +34 915854806
Fax: +34 915854760