DIRECTED ENZYME EVOLUTION GROUP AT ICP-CSIC
Welcome to Miguel Alcalde group at the Institute of Catalysis (ICP, CSIC, Madrid). Our research primarily focuses on the engineering of enzymes by directed evolution and computational design for a wide range of biotechnological purposes, the development of high-throughput biomolecular screening tools and genetic methods for library construction and exploration, as well as synthetic biology studies for environmental and energy applications.
Recent highlighted publications
Unspecific peroxygenases: The pot of gold at the end of the oxyfunctionalization rainbow?
Current Opinion in Green and Sustainable Chemistry 2023. 41,100786
A repertoire of computationally designed peroxygenases for enantiodivergent C-H oxyfunctionalization reactions
Journal of the American Chemical Society 2023.145, 6, 3443–3453.
Engineering a highly regioselective fungal peroxygenase for the synthesis of hydroxy fatty acids
Angewandte Chemie International Edition 2023, e202217372.
Miguel Alcalde Laboratory