DIRECTED ENZYME EVOLUTION GROUP AT ICP-CSIC
Welcome to Miguel Alcalde group at the Institute of Catalysis (ICP, CSIC, Madrid). Our research primarily focuses on the engineering of enzymes by directed evolution and computational design for a wide range of biotechnological purposes, the development of high-throughput biomolecular screening tools and genetic methods for library construction and exploration, as well as synthetic biology studies for environmental and energy applications.
Recent highlighted publications
Galactose oxidases engineered by directed evolution, atomistic design and ancestral sequence reconstruction
ACS Synthetic Biology. In press
A repertoire of computationally designed peroxygenases for enantiodivergent C-H oxyfunctionalization reactions
Journal of the American Chemical Society 2023.145, 6, 3443–3453.
Engineering a highly regioselective fungal peroxygenase for the synthesis of hydroxy fatty acids
Angewandte Chemie International Edition 2023, e202217372.
Miguel Alcalde Laboratory